Ole Miss vs. Louisville prediction, picks, odds, spread: Rebels open season against upset-minded Cardinals

Trinidad Chambliss leads Ole Miss into Nashville with a rebuilt receiving corps, while Jeff Brohm and Louisville look to extend a streak of top-11 upsets behind new quarterback Lincoln Kienholz. The only Week 1 game featuring two teams ranked in the preseason AP Top 25 pits No. 9 Ole Miss and No. 24 Louisville on Sunday night at Nissan Stadium in Nashville [1].

Sources

1. cbssports.com · Ole Miss vs. Louisville prediction, picks, odds, spread: Rebels open season against upset-minded Cardinals Sep 4, 2026

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