A major Alzheimer’s risk gene may shrink brain cells years before symptoms

Researchers have uncovered a possible reason why the Alzheimer’s risk gene APOE4 can disrupt the brain long before memory problems begin. In mice, APOE4 increased a protein called Nell2, shrinking neurons and making memory circuits unusually active. That early hyperactivity predicted worse memory later in life [1].

Sources

1. sciencedaily.com · A major Alzheimer’s risk gene may shrink brain cells years before symptoms Aug 23, 2026

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